Questions tagged [clinical-study]

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How to evaluate the results of diagnostic studies: how to prove that new method is better than gold standard?

I understand how to evaluate therapeutic studies: basically you compare the results of two groups that were chosen randomly. One group gets the new drug, the other group gets the placebo (or the drug ...
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What is Spanish equivalent of webpage clinicaltrials.gov?

Can you recommend any Spanish database of medical studies/clinical records, equivalent to English clinicaltrials.gov ? Medical texts should be in Spanish, not webpage necessarily.
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How has the research of the effects/benefits of yoga progressed since 2015?

Four years ago, in 2015, Vox published this piece: I read more than 50 scientific studies about yoga. Here's what I learned. I'm assuming (correct me if I'm wrong) that it's a reasonable survey for ...
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A question about clinical trials for different formulations

Suppose a new antibiotic in an iv formulation exists and has been approved When you want to test the oral formulation and phase 3 comes you should test it against what? A placebo or the iv formulation ...
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In contraceptive effectiveness ratings, are “typical use,” and “perfect use” self-reported?

The effectiveness of contraception methods is typically reported as two percentages: typical use and perfect use. Typical use is the measure of how the average couple is likely to use the method, and ...
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1answer
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Are there any studies that prove the effectiveness of saw palmetto for restoring hair in the bald places and stop hair fall?

I'm looking for studies apart from the ones in the third link in my question, that prove the efficacy of saw palmetto in 1) stop hair fall, and 2) growing back hair in the places of the scalp where ...
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Meaning of “central registration system” in Japanese clinical trials

Quote from a Japanese clinical trial report: METHOD: An observational study was conducted on patients who relapsed after primary systemic therapy with TZM using the central registration system. The ...
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Meaning of “platinum sensitivity and primary PFI being repowered as prognostic factors”

Quote from a clinical trial report: Recurrence eventually affects 70–80% of patients with advanced epithelial ovar-ian cancer [2, 22], with platinum sensitivity and primary PFI being repowered as ...
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448 views

Are “data cut off” and “data lock” the same thing in a clinical trial?

Quotes from a clinical trial report (JGOG3022 trial): Follow-up was terminated in February 2017 and data were locked in October 2017. Of the 346 patients enrolled, ineligible patients and patients ...
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1answer
59 views

What is the purpose of the “observation cohort” in a clinical trial?

Quote from a clinical trial report (JGOG3022 trial): Patients who were scheduled to receive bevacizumab concomitantly with platinum-based combination chemotherapy after PDS or IDS were included in ...
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What is the difference between “clinician” and “therapist”?

I am reading the book Mindfulness and Psychotherapy, and at first I thought clinician and therapist are used interchangeably, but it seems not. So is there any difference between the two? If yes, is ...
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Does vaccination weaken the immune system ? Studies?

A friend recognizes value in vaccinating in general - against major diseases - but with a caveat that they are opposed to the flu vaccine specifically. They claim that vaccines weaken the immune ...
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Definition of “prospective birth cohort study”

From a news article: “Prospective birth cohort studies suggest that childhood infections are associated with increased risk of schizophrenia in adulthood and with abnormal neurodevelopment in ...
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Meaning of “shared familial confounding” in a study

From a news report: Using population-based, longitudinal cohort study data from Sweden, researchers examined the relationship of infection during childhood with IQ and adult nonaffective psychosis....
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How are participants in a clinical study of a new medication selected and monitored?

I don't have any background in medicine, but I'm interested. How are participants in a clinical study of a new medication selected and monitored? Do they make an announcement calling for volunteers? ...
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Do side effects spoil blind studies?

One group is given a newly developed medication X, and the other group placebo. If X has noticeable side effects, like extra sleepiness, change in appetite, tremors, etc, wouldn't the participates in ...
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What clinical studies demonstrated that CelGro improves tissue in-growth and repair for the rotator cuff tendon injuries?

I read on https://stockhead.com.au/health/orthocell-wins-patent-for-tech-that-can-grow-you-a-new-body/ (mirror) CelGro has been shown to improve tissue in-growth and repair in clinical studies ...
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89 views

Long term side effects of Xolair

I get 300mg of Xolair injected twice a month (every 2 weeks). I was wondering if there are any studies showing long term side effects of this medicine that are not published by the manufacturers of ...
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What does “Primary Purpose: Treatment” mean in a clinical study?

At clinicaltrials.gov you can look up studies to learn more about them. On one such study, I saw this block of text: Study Type: Interventional Study Design: Allocation: Randomized ...
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Do drugs that increase (or don't decrease) mortality during clinical studies still get approved and if so - why?

From reading about clinical studies on various chronic diseases, I get a sense that increasing lifespan is rarely the primary objective of these studies, and instead they focus on surrogate markers, ...
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For a purpose of a clinical study, what is considered to be a cardiovascular death?

In the FOURIER study (to lower cholesterol with PCSK9), there is a significant reduction in different types of cardiovascular events (MI and Stroke) in the treatment group and yet the total ...
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107 views

Are there scientific studies that support the daily usage of xylitol to prevent oral problems?

Since more than 2 years I'm consuming birch sugar (xylitol) instead of sugar for basically everything and I try to avoid any product which contains sugar. Note that I wasn't consuming too many things ...
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Are there any examples of successful multi-decade prevention interventions with pharmaceuticals?

With many tests able to detect various physical abnormalities, even before symptoms develop (if ever), modern treatments may require individuals to take medications for decades. Are there any examples ...
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203 views

Multiple Sclerosis and Chemotherapy

I caught part of a cable television program but I ended up falling asleep but it seemed interesting (I was just exhausted). Basically it talked about chemotherapy being a so-far proven treatment for ...
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Good Resoures for Learning/Studying GCP

Are there any widely accepted resources out there for studying/learning good clinical practices in the U.S. outside of the actual FDA webpage for the matter? Something an entry-level clinical ...
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Are these studies about red algae reducing cold virus by 92% believable? [duplicate]

I was using this spray meant to hasten recovery from the common cold. A study [1], sponsored by the pharmaceutical company that produces the spray, stated it reduced virus by 92% (this value only ...
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Is this study stating red algae reduces cold virus by 92% believable?

I was using this spray meant to hasten recovery from the common cold. This study, sponsored by the pharmaceutical company that produces the spray, stated it reduced virus by 92%, and so shortens the ...
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Does melatonin have an effect on the treatment of type 1 diabetes?

Type 1 Diabetes is a chronic disease characterized by the body's inability to regulate blood sugar due to a disabled pancreas' not producing insulin. People with diabetes regulate their own blood ...
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Are there current studies about long term development of WPW in children?

Our daughter was diagnosed with Wolff–Parkinson–White syndrome (WPW) at zero weeks age in April 2014. I found a very interesting study from 1990 that talks about the long term development of WPW. It ...