Questions tagged [cerebral-folate-deficiency]
The cerebral-folate-deficiency tag has no usage guidance.
4
questions
2
votes
1
answer
64
views
Meaning of "Depletion of methyl-donor pool glycine, serine, and histidine" in a review article
From a review titled Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies, from Table 1:
V. Conditions affecting folate metabolism in the brain
Hereditary ...
7
votes
1
answer
70
views
Can autoantibodies found in the father affect the embryo, and how?
From "Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention" (2021):
Comparison of the Childhood Autism Rating Scale (CARS) after 2 years of ...
1
vote
0
answers
30
views
Meaning of "over-utilisation/degradation defects such as L-dopa methylation and neurodegeneration"
In Cerebral folate deficiency: Analytical tests and differential diagnosis, I came across a tough phrase:
Neurological disease was first linked to folate deficiency by Pincus and co-workers in ...
6
votes
1
answer
523
views
How does the "leucovorin rescue" work exactly? Why doesn't it make cancerous tumours grow?
Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...