Skip to main content

Questions tagged [cerebral-folate-deficiency]

Filter by
Sorted by
Tagged with
2 votes
1 answer
64 views

Meaning of "Depletion of methyl-donor pool glycine, serine, and histidine" in a review article

From a review titled Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies, from Table 1: V. Conditions affecting folate metabolism in the brain Hereditary ...
CowperKettle's user avatar
  • 1,640
7 votes
1 answer
70 views

Can autoantibodies found in the father affect the embryo, and how?

From "Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention" (2021): Comparison of the Childhood Autism Rating Scale (CARS) after 2 years of ...
CowperKettle's user avatar
  • 1,640
1 vote
0 answers
30 views

Meaning of "over-utilisation/degradation defects such as L-dopa methylation and neurodegeneration"

In Cerebral folate deficiency: Analytical tests and differential diagnosis, I came across a tough phrase: Neurological disease was first linked to folate deficiency by Pincus and co-workers in ...
CowperKettle's user avatar
  • 1,640
6 votes
1 answer
523 views

How does the "leucovorin rescue" work exactly? Why doesn't it make cancerous tumours grow?

Folinic acid is used to counteract methotrexate toxicity in cancer patients. But why exactly doesn't it counteract methotrexate's therapeutic effects? Why doesn't this "leucovorin rescue" make tumors ...
CowperKettle's user avatar
  • 1,640