Questions tagged [basal-cell-carcinoma]

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What's the success rate of Imiquimod Cream 5% recommended for the treatment of facial superficial basal cell carcinoma beyond 5 years post-treatment?

I have read several studies on the success rate of Imiquimod Cream 5% for the treatment of facial superficial basal cell carcinoma, however none of them looked at beyond 5 years post-treatment. E.g. {...
0 votes
0 answers
20 views

Does ingesting itraconazole pills increase the likelihood of success for a topical cream (Imiquimod/5-Fluorouracil) to treat BCC?

The 2014 phase II trial {1} indicates that oral itraconazole is beneficial for the treatment of basal cell carcinoma (BCC). Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have also been used to ...
3 votes
0 answers
25 views

Why are some areas of the face more likely to have basal cell carcinoma (BCC) recurrences than others?

BCC = basal cell carcinoma. I read on {4}: Certain clinical and pathological features of BCC are associated with an elevated risk for recurrence after treatment. Recurrent BCC may reappear months to ...
1 vote
0 answers
15 views

How accurate is reflectance confocal microscopy (RCM) to predict whether a basal cell carcinoma (BCC) is infiltrative or superficial?

Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that has been used to diagnose basal cell carcinoma (BCC). How accurate is RCM to predict whether a BCC is infiltrative or ...
3 votes
0 answers
26 views

What percentage of facial basal cell carcinomas (BCC) are superficial or infiltrative?

I read here (mirror): Superficial basal cell carcinoma: Approximately 10-15% of all BCCs are of this type. This is the most common pattern seen in BCCs of the shoulder. The solid (nodular) type ...
0 votes
1 answer
69 views

Why isn't imiquimod cream used prior to performing a biopsy used for suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
1 vote
0 answers
23 views

Why may a small basal cell carcinoma (BCC) treated with radiation be much more aggressive than it appears on the surface?

I read on https://www.skincancer.org/blog/ask-the-expert-why-am-i-having-surgery-to-remove-a-small-basal-cell-carcinoma/ (mirror): In addition, a small BCC in an area previously treated with ...
0 votes
1 answer
60 views

Do 50% of individuals with a history of BCC will develop another one within 5 years of diagnosis regardless of the age of the individual?

https://skinio.com/education/basal-cell-carcinoma/ (mirror) says: Patients diagnosed with BCC should be examined by their dermatologist at least twice a year. Remember, 50% of individuals with a ...
-1 votes
1 answer
29 views

How accurate is dermoscopy to predict if a skin lesion is a basal cell carcinoma (BCC), and if it is, whether it is superficial or aggressive form? [closed]

https://dermnetnz.org/cme/dermoscopy-course/dermoscopy-of-basal-cell-carcinoma/ mentions that one can use dermoscopy to diagnose basal cell carcinoma (BCC) and their subtype (nodular, superficial, etc....
0 votes
0 answers
47 views

Why isn't Imiquimod Cream 5% recommended for the treatment of superficial basal cell carcinoma located on the face?

I read on Approval Package for Imiquimod Cream, 5% on February 25, 2010 (mirror): Reference Drug (NDA number): Aldara® (imiquimod) 5% Cream (NDA 20-723), Graceway Pharmaceuticals. Date of approval: 2/...
0 votes
0 answers
26 views

How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it?

Both Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have been used to treat basal cell carcinoma (BCC) with a fair amount of success (~60 to 90% success rate at 5-year follow-up) {1}. Imiquimod ...
0 votes
1 answer
99 views

Which criteria are used to choose whether to perform a shave biopsy or a punch biopsy to diagnose suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
0 votes
0 answers
27 views

Should Imiquimod 5% cream be applied 1 cm beyond the target tumor when treating a facial basal cell carcinoma, and if so, why?

I read on https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20723s016lbl.pdf (mirror): 364 patients with primary superficial basal cell carcinoma (sBCC) were treated with Aldara Cream or ...
-2 votes
1 answer
98 views

What is the success rate of topical imiquimod 5% cream to treat infiltrative basal cell carcinoma (BCC)?

What is the success rate of topical imiquimod 5% cream (US brand: Aldara) to treat infiltrative basal cell carcinoma (BCC)? So far I've only found some case study {1} and some study on using topical ...
0 votes
1 answer
76 views

Is Imiquimod 5% cream (US brand: Aldara) helpful as an adjunctive treatment of a facial basal cell carcinoma (BCC) prior to a Mohs surgery?

I wonder whether Imiquimod 5% cream (US brand: Aldara) is not helpful as an adjunctive treatment of a facial basal cell carcinoma (BCC) prior to a Mohs surgery. Helpful in this context means 1) ...
1 vote
1 answer
95 views

How frequently does the use of topical fluorouracil cream result in permanent scarring and/or skin discoloration?

I wonder how frequently the use of topical fluorouracil cream results in permanent scarring and/or skin discoloration (e.g., hyper- or hypopigmentation). What I have found so far doesn't give any ...
0 votes
1 answer
87 views

How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC)?

I wonder how effective topical fluorouracil is to treat facial superficial basal cell carcinoma (BCC). What I have found so far doesn't give any source supporting their claims or I cannot access them: ...
0 votes
1 answer
206 views

How frequently does the use of topical imiquimod result in permanent scarring and/or skin discoloration?

I wonder how frequently the use of topical imiquimod cream results in permanent scarring and/or skin discoloration (e.g., hyper- or hypopigmentation). What I have found so far doesn't give any source ...
1 vote
1 answer
94 views

Why isn't fine needle aspiration (FNA) biopsy used to diagnose suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma, the typical first step is to do a shave biopsy to determine the type of basal cell ...