Questions tagged [basal-cell-carcinoma]

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7 votes
1 answer
74 views

What does current research show regarding the use of sunscreen in deeper skin tones?

I've struggled to find anything at all in the literature that specifically investigates the use of sunscreen as a preventative measure against sun damage in people with deeper skin tones. Furthermore, ...
Nathaniel Oats's user avatar
1 vote
0 answers
25 views

What's the success rate of Imiquimod Cream 5% recommended for the treatment of facial superficial basal cell carcinoma beyond 5 years post-treatment?

I have read several studies on the success rate of Imiquimod Cream 5% for the treatment of facial superficial basal cell carcinoma, however none of them looked at beyond 5 years post-treatment. E.g. {...
Franck Dernoncourt's user avatar
0 votes
0 answers
20 views

Does ingesting itraconazole pills increase the likelihood of success for a topical cream (Imiquimod/5-Fluorouracil) to treat BCC?

The 2014 phase II trial {1} indicates that oral itraconazole is beneficial for the treatment of basal cell carcinoma (BCC). Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have also been used to ...
Franck Dernoncourt's user avatar
3 votes
0 answers
34 views

Why are some areas of the face more likely to have basal cell carcinoma (BCC) recurrences than others?

BCC = basal cell carcinoma. I read on {4}: Certain clinical and pathological features of BCC are associated with an elevated risk for recurrence after treatment. Recurrent BCC may reappear months to ...
Franck Dernoncourt's user avatar
2 votes
0 answers
30 views

How accurate is reflectance confocal microscopy (RCM) to predict whether a basal cell carcinoma (BCC) is infiltrative or superficial?

Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that has been used to diagnose basal cell carcinoma (BCC). How accurate is RCM to predict whether a BCC is infiltrative or ...
Franck Dernoncourt's user avatar
3 votes
0 answers
28 views

What percentage of facial basal cell carcinomas (BCC) are superficial or infiltrative?

I read here (mirror): Superficial basal cell carcinoma: Approximately 10-15% of all BCCs are of this type. This is the most common pattern seen in BCCs of the shoulder. The solid (nodular) type ...
Franck Dernoncourt's user avatar
0 votes
1 answer
88 views

Why isn't imiquimod cream used prior to performing a biopsy used for suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
Franck Dernoncourt's user avatar
1 vote
0 answers
23 views

Why may a small basal cell carcinoma (BCC) treated with radiation be much more aggressive than it appears on the surface?

I read on https://www.skincancer.org/blog/ask-the-expert-why-am-i-having-surgery-to-remove-a-small-basal-cell-carcinoma/ (mirror): In addition, a small BCC in an area previously treated with ...
Franck Dernoncourt's user avatar
0 votes
1 answer
60 views

Do 50% of individuals with a history of BCC will develop another one within 5 years of diagnosis regardless of the age of the individual?

https://skinio.com/education/basal-cell-carcinoma/ (mirror) says: Patients diagnosed with BCC should be examined by their dermatologist at least twice a year. Remember, 50% of individuals with a ...
Franck Dernoncourt's user avatar
-1 votes
1 answer
30 views

How accurate is dermoscopy to predict if a skin lesion is a basal cell carcinoma (BCC), and if it is, whether it is superficial or aggressive form? [closed]

https://dermnetnz.org/cme/dermoscopy-course/dermoscopy-of-basal-cell-carcinoma/ mentions that one can use dermoscopy to diagnose basal cell carcinoma (BCC) and their subtype (nodular, superficial, etc....
Franck Dernoncourt's user avatar
0 votes
0 answers
49 views

Why isn't Imiquimod Cream 5% recommended for the treatment of superficial basal cell carcinoma located on the face?

I read on Approval Package for Imiquimod Cream, 5% on February 25, 2010 (mirror): Reference Drug (NDA number): Aldara® (imiquimod) 5% Cream (NDA 20-723), Graceway Pharmaceuticals. Date of approval: 2/...
Franck Dernoncourt's user avatar
0 votes
0 answers
28 views

How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC) after Imiquimod 5% cream failed to treat it?

Both Imiquimod 5% cream and topical 5-Fluorouracil (5-FU) have been used to treat basal cell carcinoma (BCC) with a fair amount of success (~60 to 90% success rate at 5-year follow-up) {1}. Imiquimod ...
Franck Dernoncourt's user avatar
0 votes
1 answer
111 views

Which criteria are used to choose whether to perform a shave biopsy or a punch biopsy to diagnose suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma (BCC), the typical first step is to perform a shave biopsy to determine the type of ...
Franck Dernoncourt's user avatar
0 votes
0 answers
27 views

Should Imiquimod 5% cream be applied 1 cm beyond the target tumor when treating a facial basal cell carcinoma, and if so, why?

I read on https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20723s016lbl.pdf (mirror): 364 patients with primary superficial basal cell carcinoma (sBCC) were treated with Aldara Cream or ...
Franck Dernoncourt's user avatar
-2 votes
1 answer
116 views

What is the success rate of topical imiquimod 5% cream to treat infiltrative basal cell carcinoma (BCC)?

What is the success rate of topical imiquimod 5% cream (US brand: Aldara) to treat infiltrative basal cell carcinoma (BCC)? So far I've only found some case study {1} and some study on using topical ...
Franck Dernoncourt's user avatar
0 votes
1 answer
80 views

Is Imiquimod 5% cream (US brand: Aldara) helpful as an adjunctive treatment of a facial basal cell carcinoma (BCC) prior to a Mohs surgery?

I wonder whether Imiquimod 5% cream (US brand: Aldara) is not helpful as an adjunctive treatment of a facial basal cell carcinoma (BCC) prior to a Mohs surgery. Helpful in this context means 1) ...
Franck Dernoncourt's user avatar
1 vote
1 answer
119 views

How frequently does the use of topical fluorouracil cream result in permanent scarring and/or skin discoloration?

I wonder how frequently the use of topical fluorouracil cream results in permanent scarring and/or skin discoloration (e.g., hyper- or hypopigmentation). What I have found so far doesn't give any ...
Franck Dernoncourt's user avatar
0 votes
1 answer
92 views

How effective is topical fluorouracil to treat facial superficial basal cell carcinoma (BCC)?

I wonder how effective topical fluorouracil is to treat facial superficial basal cell carcinoma (BCC). What I have found so far doesn't give any source supporting their claims or I cannot access them: ...
Franck Dernoncourt's user avatar
0 votes
1 answer
275 views

How frequently does the use of topical imiquimod result in permanent scarring and/or skin discoloration?

I wonder how frequently the use of topical imiquimod cream results in permanent scarring and/or skin discoloration (e.g., hyper- or hypopigmentation). What I have found so far doesn't give any source ...
Franck Dernoncourt's user avatar
1 vote
1 answer
97 views

Why isn't fine needle aspiration (FNA) biopsy used to diagnose suspected facial basal cell carcinomas?

Given a neoplasm of uncertain behavior of skin on a patient's face that is suspected to be a basal cell carcinoma, the typical first step is to do a shave biopsy to determine the type of basal cell ...
Franck Dernoncourt's user avatar