Questions tagged [antivirals]

Antiviral drugs are a class of medication used for treating viral infections. They are different to antibiotics.

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Why the FDA-approved drug label for sofosbuvir mentions "Without cirrhosis or with compensated cirrhosis" as indication?

SOVALDI is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of: - Adult patients with genotype 1, 2, 3 or 4 chronic hepatitis C virus (...
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What is the meaning of "co-formulated"?

I was reading the The right drug for the right patient section of the University of Sydney website, which provides these clinical guidelines (flow chart), and says (bold my own): There are no studies ...
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Why should males use contraception for longer after taking molnupiravir for COVID?

Molnupiravir (brand name Lagevrio) is a small-molecule antiviral prodrug active against SARS-Cov-2 and in one trial was found to reduce risk of hospitalization or death from COVID by 52% (Jayk Bernal ...
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Was KP-1461 found to be not a good drug?

Everything I've been able to find out about the drug (which is a prodrug, I could glean that it becomes KP-1212 inside the cells, in a process involving triphosphorylation) sounds very promising ...
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Are there *in vitro* studies that find ivermectin directly effective against the SARS-CoV-2 spike or its other proteins?

Among the more obscure papers proposing ivermectin as a treatment for Covid-19 there are some that suggest it acts directly by binding to the SARS-CoV-2 spike protein (and other proteins of that virus ...
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(Why) are there so few studies of ivermectin as an antiviral in animal models?

I've been trying to understand the ivermectin controversy (especially in view of NIH's recent [partial] change of heart). Based on one of the more recent papers (Jans & Wagstaff) which proposes ...
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Fact check: Was remdesivir treatment associated with a 62% reduction in mortality rate?

On July 10, 2020, Gilead announced remdesivir treatment was associated with significantly improved clinical recovery and a 62 percent reduction in the risk of mortality compared to standard of care......
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For the people who are treated with interferons, does this provide them extra protection against corona virus?

It is known that interferon inhibits the viruses replication process. At the same time, they don't give it to people with COVID-19 because we don't want the flu-like symptoms to get worse. How about ...
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How is Lopinavir + Ritonavir expected to stop COVID-19?

There are four drugs being tested for effectiveness against COVID-19 in the SOLIDARITY trial. Three of them have obvious potential mechanisms of action: Remdesivir is an RNA polymerase inhibitor. ...
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Can oseltamivir shorten the duration of COVID-19 and inhibit replication and transmission of the SARS-CoV-2 (2019-nCoV) virus?

Oseltamivir (Tamiflu) is an antiviral medication used to treat and prevent influenza A and influenza B (flu). It is said to reduce symptom duration even when initiated more than 2 days after symptom ...
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Could the Cuban coronavirus antiviral be a mass cure for COVID-19?

Sometime around 1981, the Cubans invented an antiviral treatment for coronavirus. What is its relative efficacy against COVID-19? What are the pathways and obstacles for it making its way to being a ...
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Continuing effectiveness of anti-viral drugs after shingles outbreak

When shingles is treated with famciclovir for a few weeks and the rash disappears but the pain persists, can another course of treatment with famciclovir reduce pain? If not, what other medications ...
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How effective is oseltamivir when given before symptoms of flu appear?

A day before someone gets symptoms of flu, it can already been detected that the person will get the flu, as the person is already contagious. Would an antiviral like oseltamivir (Tamiflu) then be ...
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For Varicella zoster (chicken pox), when are vaccination/antiviral drugs effective?

The UK does not routinely vaccinate its citizens against chickenpox though the info website of the chief healthcare provider acknowledges that vaccinations are available and there are also ...