Why do pupils dilate when someone says a lie? What are other physical symptoms when someone is lying?
Is there a truth serum? Or is that a myth?
The phenomenon you are describing of the pupils dilating when telling a lie has to do with the way the muscles around the eye are wired to the nervous system, and more specifically, the autonomic nervous system.
For better understanding, I suggest reading the chapter about neurotransmission in any introductory pharmacology book, such as Katzung's Basic and Clinical Pharmacology (chapter 6 in 12th edition), or Goodman & Gilman's The Pharmacological Basis of Therapeutics (chapter 8 in 12th edition). However, I will try to explain it briefly here.
The autonomic nervous system (ANS) regulates bodily functions that occur without conscious control (involuntary actions). This system is divided into two branches: The sympathetic nervous system and the parasympathetic nervous system; each can be described by a short general statement, as follows: The sympathetic system is more active in a "fight or flight" situations, and the parasympathetic system is more active in a "rest and digest" state. In other words, the sympathetic nervous system adjusts your body to deal with some kind of threat to your safety, whereas the parasympathetic nervous system adjusts your body to conserve energy and be efficient when resting (i.e. good sleep,good digestion etc.)
Now, lying usually involves some level of tension or anxiety (unless you are a very good liar), because you might be worried to a certain degree that the lie will be revealed. This tension subconsciously triggers the sympathetic nervous system, which will cause certain effects throughout your body. Sympathetic stimulation to the eye will cause contraction of the radially oriented pupillary dilator muscle fibers in the iris and will result in mydriasis (dilation of the pupil). An opposite effect is achieved when the eye receives parasympathetic stimulation (i.e. when you are calmer, maybe after confessing the truth...), and the pupil undergoes miosis (constriction).
In short, since lying usually involves tension, and tension is associated with increased sympathetic activity, the pupil will dilate following sympathetic stimulation.
This point leads us to the other part of your question: other physical symptoms of lying are actually other manifestations of increased sympathetic activity (for a more thorough review, please see the texts I recommended above). Among others, common effects are: rise in blood pressure,increased heart rate, and increased sweating.