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So...I'm 30 years old and have Tourette's syndrome since 9. I never took any medication because most of then are antipsychotics and have very scary side-effects.

Now, apparentely some antihypertensive can help too. Not as much as the anti-psychotics but they can help. And with much less side effects too.

However, they obviously lower your blood pressure, (that's what they are made for after all) so if your pressure is average it will drop.

My question is: Is it Possible/Safe/Reasonable to take some medication to increase your blood pressure, so it returns to normal? If not, and one just have to deal with low blood-pressure...How to deal with low blood-pressure?

  • When you ask "how to deal with low blood pressure", do you mean a particular symptom associated with low BP? If so, please describe. If not, there's not much to "deal with", but perhaps you want to ask if there are any risks of having too low BP? – Susan Aug 17 '16 at 8:11
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Following paper Tourette’s Disorder. Lyon, G.J., Shprecher, D., Coffey, B. et al. Curr Treat Options Neurol (2010) 12: 274. doi:10.1007/s11940-010-0073-x provides a good (somehow recent) review on Tourette's disorder and its therapeutic management.

Indeed, antihypertensive therapies are considered as potential therapeutic management in TD.

One recent open-label, prospective 8-week study of guanfacine (at an average dose of 2.0 ± 0.6 mg/d) enrolling 25 medication-free participants (23 males and two females), ages 7–16 years, showed a mean improvement of 27% on the Hyperactivity Index, 32% on the total score of the teacher-rated ADHD Scale, and 39% on the total tic severity scale.

As I don't know whether this review in open access or not, here some extracts which may bring some clarifications:

Alpha-2 adrenergic agonists

Drugs in this class have demonstrated efficacy for both tics and ADHD in randomized clinical trials, so this class is a good first-line choice for patients with both conditions.

There is class I evidence for efficacy of oral clonidine [3, Class I]. Guanfacine is used in clinical practice with similar efficacy, a more favorable side effect profile, and more convenient (daily or twice-daily) dosing.

One class I study has now demonstrated the efficacy of the clonidine transdermal system (patch) for tic disorders.

Standard dosage

Guanfacine (1 mg tablets) can be started at one half tablet at bedtime and increased by half a tablet every 3–7 days until the maximum dose of 4 mg per day is reached. Extended-release guanfacine is now available in nongeneric formulation. For those who fail to tolerate guanfacine, treatment with clonidine in adults can begin with one half of a 0.1-mg tablet at bedtime, increasing the dose by half a tablet every 3–7 days until the target dose of one half to one tablet two to three times a day is reached. The maximum dose is typically 0.4 mg daily in divided doses. Starting doses for clonidine and guanfacine in children can be half of adult doses.

Contraindications Known hypersensitivity to the product.

Following extract adresses your concern about low blood pressure

Main side effects Both clonidine and guanfacine are associated with sedation, fatigue, and somnolence. Reductions in heart rate and blood pressure are modest and rarely lead to discontinuation of treatment.

Obviously according to several studies, the clonidine/guanfacine doses used in TD are not associated with a significant drop in BP. Initiation of the therapy should be undertaken by your treating doctor who will undertake some follow-ups to ensure that you are not suffering from any side-effects.

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