I have read that paracetamod+ibuprofene (P+I) is not much better than ibuprofene alone (IA).

However I noticed that P+I is better than IA for fever, for me. I wonder if it is possible that there are some genetic or other individual factors that would explain why I noticed that P+I is better for fever (and related muscle aches ) than IA.

The background story is the following: I took 1600 mg Ibuprofen in the last 18 hours and my muscle ache and fever (37,3) did noe want to go away (I got some viral upper respiratory infection). Then I took paracetamol 500 mg and 1 hour after that I started sweating and suddenly got much better. Any idea why this might have happened ?

Related : https://biology.stackexchange.com/questions/2440/is-it-better-to-take-a-half-dose-of-paracetamol-and-a-half-dose-of-ibuprofen-tog

1 Answer 1


Ibuprophen is an non-steroidal anti-inflamatory drug (NSAID). As it's name indicate, it reduces inflammation, which can reduce the discomfort of a fever.

Paracetamol (called Acetaminophen on my side of the pond) is an analgesic which reduces pain. While not an anti-inflammatory, it does help reduce the symptoms by cutting down on the amount of aching and fever that you feel.

This is a recommended combination when trying to manage mild to moderate pain without resorting to morphine or other opioid medication. A counter-indication to this combination is gastro-intestinal bleeding. Don't forget to follow the posologie and recommendations of each individual medication

  • This answer does not address antipyresis which the question is about! How is this the correct answer?
    – whitebeard
    May 20, 2019 at 6:13
  • @whitebeard It does... Despite not being an antipyretic, Tylenol provides the patient with pain/discomfort relief. If you want you can modify my answer.
    – enap_mwf
    May 24, 2019 at 20:09
  • 1
    While not anti-inflammatory, it does have antipyretic effects. From: drugs.com/ppa/acetaminophen.html Antipyresis is produced from inhibition of the hypothalamic heat-regulating center.
    – whitebeard
    Jul 29, 2019 at 6:07

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.