As we know hair turns gray or white hair due to a lack of pigmentation and melanin.

This article and study from 2009 and 2013 suggest that accumulation of H2O2 is due to oxidative stress which can affects human hair color leading to low serotonin and melatonin levels.

So it seems that elevated amounts of hydrogen peroxide can be the main cause of gray hair. Therefore removing/dissolving hydrogen peroxide from hair follicles (under the scalp) and hair shafts would help to reverse going gray from age. Is that correct?

I'm asking for interpretation of above studies. If so, does it mean we've already a cure for gray hair? What are these cures?

So far I've heard about depo-melanin containing some acid which could potentially dissolving hydrogen peroxide under the scalp to prevent gray hair and this is what they claim:

Depo-melanin is a 100% drug free hair serum that is formulated with the main ingredients of pseudocatalase and catalase, which is scientifically proven to prevent gray hair.

Is that true? Does it mean we've the cure for gray hair? Or there are any other cures?

  • My bet would be on stem cells as a "cure." Commented Apr 27, 2015 at 3:47
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    This is the article cited ... Full text is available, but I lack the expertise to judge it, and judge if it actually corresponds to the product being sold ... However, products marketed as "100% drug free" and claims followed by several exclamation marks do set off my bullshit detector ;-) Commented May 1, 2015 at 21:58

1 Answer 1


The study did not investigate the causes of, or possible treatments of, grey hair. However, the research focused on vitiligo, specifically looking at segmental vitiligo (NHS, 2013).

The NHS went further by saying that:

Though the blame for the poor reporting of the study can be put at the door of the press office of the FASEB, which issued a press release almost entirely focused on the grey hair angle. This is a textbook example of public relations officers ‘sexing up’ a dry but worthy piece of research in order to gain maximum media coverage. And – credit where credit is due – they did an excellent job of that. Unfortunately, in doing so they obscured the truth.

Whether peer-reviewed journals should be engaging in these types of disingenuous practises, which arguably damage the public understanding of science, is a matter of debate. However, FASEB are not alone in this, as recent research found that academics, journals and news reporters all share the blame for the spin found in around half of all medical reporting. (NHS, 2013).

What the NHS was reporting on was that there were a number of newspaper articles in 2013 talking about a 2013 study by one of the researchers in the 2009 study (Karin U. Schallreuter) - Schallreuter et al. (2013). Strangely enough, looking at the 2009 study, they also tested the theory on vitiligo patients.

By analogy, we turned to vitiligo, a depigmentation disorder, as this model could hold lessons for a better understanding of the graying process (Wood et al. 2009).

In explaining the problem, the NHS points out that:

Vitiligo can be divided into two forms: segmental and nonsegmental vitiligo. Nonsegmental vitiligo is the more common, in which the white patches that appear are symmetrical (the same places on both sides of the body, for example both hands could be affected). In nonsegmental vitiligo, two chemicals – hydrogen peroxide and peroxynitrite – accumulate in the skin.

Nonsegmental vitiligo can be treated with a pseudocatalase, which is activated by narrow-band UVB light. This reduces the concentrations of hydrogen peroxide, allowing the lost skin colour to return.

In the less common segmental form of vitiligo, the affected skin lies in a dermatome, which is a particular area of skin supplied by a single nerve, so it usually affects only one side of the body.

Segmental and non-segmental vitiligo can also co-exist, giving rise to ‘mixed’ vitiligo.

This study aimed to see whether the accumulation of hydrogen peroxide and peroxynitrite which occurs in nonsegmental vitiligo also occurs in segmental vitiligo, and if so, if the light activated pseudocatalase could also be of use in segmental vitiligo.

The bottom line is that, as far as I have seen, it has not been proven whether the accumulation of hydrogen peroxide is the cause of grey hair or not.


NHS (2013). No evidence of cure to prevent hair going grey. Retrieved from: https://www.nhs.uk/news/medication/no-evidence-of-cure-to-prevent-hair-going-grey/

Schallreuter, K. U., Salem, M. A., Holtz, S., & Panske, A. (2013). Basic evidence for epidermal H2O2/ONOO-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. The FASEB Journal, 27(8), 3113-3122. doi: 10.1096/fj.12-226779

Wood, J. M., Decker, H., Hartmann, H., Chavan, B., Rokos, H., Spencer, J. D., ... & Schallreuter, K. U. (2009). Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. The FASEB Journal, 23(7), 2065-2075. doi: 10.1096/fj.08-125435

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