I have been amazed at the accurate and pertinent results from some services such as NutriHacker (via data from 23andMe.com or DNA.Ancestry.com). This has allowed me to take my nutritional supplementation certainty to a much higher level that has been corroborated medically.

One thing that I have traditionally observed, from my own experience, is that some probiotic bacteria and yeast have left me feeling ill and caused bowel problems. No one has been able to ascribe a why to this or what regimens would be best for my particular scenario.

This has led me to think: are there studies that indicate that certain probiotics are better for individuals with certain genetic profiles?

If anyone has seen such studies or know of such research, a sharing of this would be much appreciated. I think having this information would lead to a much better overall level of health for many of us vs stabbing in the dark, which most doctors and nutritionists have recommended to me so far.

  • It would help to know what probiotics you are taking as not all the commonly available probiotics have been declared completely safe or beneficial medically.
    – Ben Cannon
    Apr 15, 2016 at 19:23
  • @BenCannon I've used quite a number over the years and cannot enumerate them all, but none have yielded good results. Most recently I've taken bacillus coagulans (5B) which seemed to do nothing. About a year ago, I took this from GNC and became extremely ill about a week after taking it with serious GI complications and have had to be on a periodic PPI since. Obviously my goal here is to REMOVE the guesswork and find out if there are genetic markers that indicate successful regimen per alleles, even if I have to manually pour over appropriate studies.
    – ylluminate
    Apr 15, 2016 at 19:41
  • What do you mean by genetic profile? Apr 15, 2016 at 21:35
  • @GrahamChiu meaning the full genetic raw data provided by services like 23andMe.com and Ancestry.com. Eg, 23andMe.com allows you to not only browse, but download your full raw genetic profile.
    – ylluminate
    Apr 15, 2016 at 23:35
  • 1
    It was Peer Bork, head of this group: embl.de/research/units/scb/bork/index.html and member of the IHMC. I have no further references.
    – rumtscho
    Apr 21, 2016 at 13:02


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