My wife currently has a cold sore. I currently don't. I've had cold sores before, which means that (most probably) HSV-1 lies dormant somewhere in my body.

If I kiss my wife while she is has a cold sore, will this this trigger a recurrence?

I've tried to research this question, but the information I find online does not help much:

  • If the virus already lies dormant within me, additional exposure shouldn't matter. --> KISS

  • On the other hand, most "how to prevent getting cold sores ever again" websites online say that you should avoid exposure to infected people (without further explanation; in particular, without addressing the previous point). --> DON'T KISS

  • How often do you get recurrences? This might matter (especially if you've never had one.) – anongoodnurse Mar 17 '16 at 22:46

Original answer

You are already infected. The HSV is indeed dormant in your body. It keeps trying to get out, till your immune system is off guard and it will present as a cold sore. So when you don't have a cold sore your immune system is in control and you can't get "more infected" by your wife. So you can kiss without worries.

The next question is, do you really want to if she has a sore ;)

Update: I'm new here, i thought I keep it simple. I will try to provide some evidence and complete the answer:

HSV-1 infects mucosal cells, like the ones in mouth and genitalia. After infection the HSV virus infects innervating neurons causing a latent infection. While the mucosal cells are infected, CD8+ cells (which kill virus infected cells) "learn" to recognize the virus and kill it of. As long as your CD8+ cells function normally the virus cannot reactivate. Also antibodies agains the infecting virus are formed, protecting against reinfection (theoretically you could also reinfect yourself) (1)

As @YviDe pointed out it is possible to get infected with multiple strains. In this a small study with 13 HSV-1 infect persons 2 where infected with more than 1 strain (2) However, there is also evidence an infection with HSV can protect against an infection with another strain. (3)

Now, lets assume you and your wife have the same strain of virus. Then the likelihood of you reinfecting yourself is much higher than she infecting you, since you drink from your infected glass and use your infected toothbrush etc.

If she has a different strain things are uncertain. As pointed out, your current infection could protect you but depending on numerous factors you can get reinfected or not with the different strain. If you have a cold sore your immune system (partly) compromised, so at that moment your susceptibility for a infection by this different strain is probably higher. However, changes that you get infected anyway while living under the same roof is pretty high.

If I where you, I would worry about it to much since you can't be sure about anything without genetic sequencing of your and your wifes HSV-1 virus.

(1) Egan KP et al, Immunological control of herpes simplex virus infections, 2013

(2) Roest RW et al, Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes, 2014

(3) Stanberry LR et al, Longitudinal risk of herpes simplex virus (HSV) type 1, HSV type 2, and cytomegalovirus infections among young adolescent girls, 2004

  • This information is already contained in the question. It doesn't provide an answer. – Carey Gregory Mar 20 '16 at 14:53

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.