I have problem in understanding what it really means that antagonist is irreversible.
I have an allergy and I stopped to take some drugs because of side effects.
I tried to predict how long does it take to go to the same state as before taking drugs.
I learned about biological half-life of medicines so I could predict how long it will take for drug to stop being active.
But then I read that my antihistamine drug is an irreversible antagonist.
I’ve checked the definition, and if I understand it, this means that the receptors are permanently blocked through some reaction with this antagonist.
The question is:
Does it mean that this cell which receptors are blocked is defective forever?
And side effects will never go away because, in this case, cell needs histamine to work properly?
Or we must wait for the cell to die and be replaced by new cell?
Sorry if my questions are not on appropriate level.