Wang, Allan W., et al. "Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete." BMJ case reports 2013 (2013): bcr2012007899. voices some phenotype instability concerns regarding the injection of collagen-producing skin-derived tenocyte-like cells, when treating a tendinopathy:
In the patella tendon, [platelet-rich plasma] and other cell based approaches have been used for the treatment of tendinopathies. In a recent level-1 randomised controlled trial, collagen-producing skin-derived tenocyte-like cells have been shown to be superior regarding recovery time, pain and function compared to plasma injections alone.
Despite these promising results, instability of the phenotype is a concern as skin-derived cells are non-homologous to tendon tissue.
Has any medical trial confirmed or infirmed that the injection of collagen-producing skin-derived tenocyte-like cells results in deleterious phenotype instability?