According to several medical resources, Smith-Lemli-Opitz Syndrome (SLOS) is congenital and caused by mutation, e.g.
Smith-Lemli-Opitz syndrome is caused by mutations in the DHCR7 gene, the gene that codes for the enzyme DHCR7 that normally converts 7DHC to cholesterol in the final step of the cholesterol synthetic pathway. - Reference
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. - Reference
A friend of mine, who is 4-month pregnant, recently took a medical test giving her a high probability (1 in 8 as the test paper says) of SLO Syndrome. She has mistakenly (not knowing she was pregnant) taken Diane-35 under her doctor's prescription for 21 days in her early pregnancy. Now my question is, given that no mention has been made of drug intervention relationship with the syndrome in the medical resources, at least in those I checked, and that she already has a successful pregnancy background, can SLOS be caused due to drugs? In case of abortion, how can she make sure whether she or her husband is carrier of the syndrome for future pregnancies?