I have pseudocholinesterase deficiency (BCHE gene), but my wife does not. My wife may need/strongly desire an epidural for our next child. Is this safe for a fetus which may possibly have the same condition as me? If not, then what is a safe alternative?

One specific drug I'm concerned about is bupivacine, which, I read affects me more powerfully than the typical person.

I have read the information from 23 and me about this condition. I have read "Pseudocholinesterase Deficiency: A Comprehensive Review of Genetic, Acquired and Drug Influences". None of the articles I have read with pregnancy being mentioning dealt with this condition except to mention that pregnancy often leads to a acquired deficiency.

  • Welcome to the site. Just out of curiosity, how much research have you done about this? For example, there are genetic and acquired PCD, and if yours is acquired, can it be passed on? Also, what class of drugs can't you metabolize? What class of drugs is bupivacaine? Sometimes a bit of research presented will get you an answer. – anongoodnurse Oct 25 '15 at 1:32
  • I have read more about my condition on 23andme for which I am heterozygous. 23andme detected the following variants: Gly390Val (F2). The "fluorine resistant 1" (F1) and "fluorine resistant 2" (F2) mutations are so named because they affect another type of blood test that uses fluorine. – haleonj Jan 16 '16 at 15:38
  • This reading didn't help because I need to know about heterozygotes, like myself, and that is typical of the reading I have encountered. – haleonj Jan 16 '16 at 15:40

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