# Comparitive exposure to spike protein between mRNA vaccines and an actual Covid infection

Do we have any data or estimation regarding the relative spike protein exposure between an mRNA vaccine and an actual Covid infection?

This is a complicated question.

Assume two identical humans are there, one gets mRNA vaccine and one gets an actual Covid infection.

1. Now how much covid cells is the infected person exposed to during the course of the disease? The peak virion load is about 1 to 100 billion in Covid inflected patients. Source. But this is a snap shot of peak load, we need area under curve to know total load over the period of infection. See the below figure

2. How does this compare to the total amount of spike protiens generated by mRNA vaccines in the body?

These are the previous links I got but I didn't find the relevant data here

Is Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose?

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

The total number and mass of SARS-CoV-2 virions

• This is a very difficult question to answer - a large part of the viral output will be "outside" the body - into the lung spaces of the lungs, into the gut lumen as the virus replicates mostly in the epithelial tissues. There is some immune exposure from this, but characterizing just how much is in the impossible category. We can do a first-order calculation of how many transcripts are injected per vaccine dose and how many RNA are produced in an infection though...
– bob1
Sep 4, 2023 at 22:50
• ...see last part of this answer by me here for viruses and here for RNA per vaccine on Biology SE respectively
– bob1
Sep 4, 2023 at 22:55
• @bob1 thanks a lot. Do you know how many spikes per covid viron cell?? And how many spike protiens does one mRNA is capable of generating before deteriorating? We already know at peak infection there are 10^9 to 10^11 cells in body. Sep 5, 2023 at 7:04
• @HariKumar cells? Do you mean virions? Try this for some info.
– bob1
Sep 5, 2023 at 8:25
• @bob1 thank you. Is there any way to estimate the total spike protiens created by a single mRNA before it deteriorates? Sep 5, 2023 at 9:38