From the International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis, table 4:

Maintenance (>6 mo) immune suppression:
Rituximab redosing (same doses as above or reduced dose as per local recommendations) when repopulation of CD19 occurs (or about 6 mo after the first course)

Does "redosing" mean "retain the same daily dose, but split it, so that the drug is taken more often in smaller portions"? I found such definition in Wiktionary.

Then why does it say "same doses as above"? This way, the daily dose would increase, wouldn't it?

  • 1
    In this case, redosing means “infuse the same dose of rituximab as the last dose administered or reduced as per local recommendations.” I didn’t read the source, but it’s a maintenance dose. Other than weight adjustment, there’s no need to increase.
    – Ian Campbell
    Aug 13, 2022 at 10:23


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