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I'm reading contradictory statements.

{2} states:

Two freeze/thaw cycles (with a shorter freeze time) are more effective for thicker lesions such as seborrhoeic keratosis and warts.

However, {3} states:

The treatment is repeated in some cases, once thawing has completed. This is known as a ‘double freeze-thaw’.

and {1} states that for warts, double freeze-thaw cycle confers little or no advantage over a single freeze in some location:

The use of a double freeze-thaw cycle confers little or no advantage over a single freeze in the treatment of hand warts, but may be considerably more effective for plantar warts.

and {4} says that repeat freeze-thaw cycles generally are employed only in the treatment of malignancy:

Slow thaw times and repeat freeze-thaw cycles produce more tissue injury than a single freeze and thaw. Usually, several minutes are allowed between repeat freeze-thaw cycles. Repeat freeze-thaw cycles generally are employed only in the treatment of malignancy.

What's optimal from a cosmesis standpoint between applying a single or a double freeze-thaw cycle to treat a thick seborrhoeic keratosis?


References:

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