I would like to learn about the effectiveness of vaccines against the omicron variant of the coronavirus. I believe a review article from a scientific journal would have the best information. I would prefer a review article over a paper about an individual study, since a review would summarize what is known from various studies. I was not trained in biology or medicine, but I do have a PhD in a scientific field (physics). Given that I am a scientist, I believe I should be able to generally understand an article in a scientific journal. I have searched Google Scholar. However, since neither biology nor medicine is my area of expertise, I am having trouble deciding which articles are authoritative.

I am looking for a review which is considered authoritative by doctors and biologists, and I would appreciate someone pointing me to such an article. I would prefer a review which was published relatively recently in a journal with a high impact factor, and which has a fairly high number of citations. However, I understand that the more recent an article is, the fewer citations it can be expected to have.

I am not trying to decide whether to get vaccinated; I am fully vaccinated, and I received my booster shot. I simply want to find out how well vaccines protect against infection and serious illness from the omicron variant.

Thank you.

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    HI Casper, welcome to Medical Sciences. I have some feedback that is my personal opinion. First, this question is interesting and important (and it doesn't seem like we've addressed this one in a while). However, it reads like a lot of requirements about what exactly you want. I think it would be better if a lot of your personal details were not included. Also, it doesn't include any prior research. What did you find that wasn't up to standard? I can make some attempts at an edit if you're open to it.
    – Ian Campbell
    Mar 13, 2022 at 14:07
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    Omicron is only 4 months old, so I‘m not sure if there any reviews in high IF journals yet because the peer-review process is likely to take a month or more, and there needs to be time for primary studies to be conducted as well.
    – Narusan
    Mar 13, 2022 at 14:37
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    A PubMed search with these keywords „ ((Omicron) AND (Review[Publication Type])) AND (vaccine[Title/Abstract])“ did not yield any good results. I think a better option would be to look at primary articles…
    – Narusan
    Mar 13, 2022 at 14:43
  • @IanCampbell Thank you for the suggestions. I agree that I probably put too many requirements into my question. Narusan sent me a link to a paper on a good study. That was helpful. Mar 14, 2022 at 5:37

1 Answer 1


I do not think that there are any reviews available yet - the first high quality studies regarding vaccination efficacy against Omicron have just recently been published. A PubMed search with the keywords ((Omicron) AND (Review[Publication Type])) AND (vaccine[Title/Abstract]) did not give meaningful results yet.

A good case-control study is this study in the New England Journal of Medicine, published 11 days ago. A case-control study is still fairly low on the quality pyramid of evidence based medical research, but there has simply not yet enough time passed for good experimental studies:

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There are also quite a few good articles on virus neutralisation in vitro, which is only a proxy for vaccine efficacy in vivo.


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