I got a question from a textbook <<Seeley's Anatomy & Physiology Twelfth Edition>> that does not have an answer at the back of the book (only odd numbered questions do have an answer and this question is even):
In addition to targeting the bacteria for death, what is one theoretical medical approach that could help reduce the amount of bone loss during osteomyelitis?
I found a paper that suggests 3 methods:
- Antibiotics targeting the bacteria (but that is targeting the bacteria for death
- Surgical debridement of dead tissue (including sequestrum) or biofilm produced by the bacteria
- Hyperbaric oxygen treatment, which puts patient in a high pressure pure oxygen environment will result in immunomodulation, reduction in pro-inflammatory mediators. This is helpful because bone loss in osteomyelitis is also caused largely by host's inflammatory chemical damaging the bone.
Another paper only suggest antibiotics and surgical methods. I look through a few other and there seemed to be no other methods to help reduce bone loss during osteomyelitis.
However, i am not sure if there is any other ways to reduce bone loss during osteomyelitis. Please help me by suggesting other methods that i may have missed out.