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In the short term, the effects of caffeine are well studied both as a vasodilator and vasoconstrictor, but given that chronic use produces specific adaptations, is the long term effect of caffeine use reduced or increased blood flow to connective tissue?

https://www.independent.co.uk/life-style/health-and-families/health-news/drinking-coffee-significantly-improves-blood-flow-study-finds-8952276.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748160/

https://www.ncbi.nlm.nih.gov/books/NBK202224/

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With regard to underlying biological mechanisms, most research has been devoted to BP-raising effects of caffeine. However, there are many other substances in coffee, such as polyphenols, soluble fibre and potassium, which could exert a beneficial effect in the cardiovascular system. Although the precise nature of the relation between coffee and BP is still unclear, most evidence suggests that regular intake of caffeinated coffee does not increase the risk of hypertension.

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  • Welcome to MedicalSciences.SE. Is blood flow to the tissues only increased with higher blood pressure? I am not sure this answers the question. Jul 30 at 7:20
  • Blood pressure is the two main factors: 1- Output of the heart 2- Vascular resistance : BP=output*VR ,and Vascular resistance depends on the diameter of the vessel, the intensity of the flow, and the viscosity of the blood
    – Salio
    Jul 30 at 7:53
  • But, is an increase of blood pressure all that is required to increase blood flow to connective tissues? Jul 30 at 7:57
  • Look at the relationship above
    – Salio
    Jul 30 at 7:59

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