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Most places I have looked e.g NHS and Mayo Clinic state that,

  • It's best to take metformin with a meal to reduce the side effects.

  • The most common side effects are feeling and being sick, diarrhoea, stomach ache and going off your food.

Yet, I just came across Hashimoto, et al (2016) who states that,

Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism.

[...]

Taking metformin 30 min before a meal ameliorated postprandial hyperglycemia. This promises to be a novel approach for postprandial hyperglycemia.

So, has Hashimoto's team proved that normal advice is wrong and Metformin should be taken 30 minutes before a meal?

References

Hashimoto, Y., Tanaka, M., Okada, H., Mistuhashi, K., Kimura, T., Kitagawa, N., Fukuda, T., Majima, S., Fukuda, Y., Tanaka, Y., Yamada, S., Senmaru, T., Hamaguchi, M., Asano, M., Yamazaki, M., Oda, Y., Hasegawa, G., Nakamura, N., & Fukui, M. (2016). Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, open-label, crossover pilot study. Endocrine, 52(2), 271–276. https://doi.org/10.1007/s12020-015-0786-4

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