I'm reading about the toxicology of LSD, and the acute and subacute adverse effects (hypertension, hyperthermia, tachycardia) have been described as moderate in this article, modest in this article (page 2) and significant in this article (page 10). The second article cites the first and third articles when stating the modesty of the aforementioned effects.
By what standards are they designating these acute and subacute adverse effects moderate? Is there a scale one can look at to give the different safety levels of the intensity adverse reactions to pharmacological agents relative to their duration? According to this article, if one were to have these blood pressures chronically, then it'd be a problem. However, these effects are only acute, which probably increases the safety levels. According to the the first and third articles, there was little to no increase in adverse reaction between the LSD-ingesting and placebo-control groups.