After vaccination with BBIBP-CorV (inactivated) which of the following tests can be taken to determine if the vaccine produced an immune response:

  1. IgM for N protein
  2. IgG for N protein
  3. IgG for S protein

Sorry if it's obvious, but I'm not an expert and cannot find a clear answer after googling for an hour.
My current understanding that it's test 2 - IgG for N protein for inactivated vaccines.

1 Answer 1


TL;DR; 3 - IgG for S protein

From Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial:

The secondary outcome was immunogenicity, assessed as the neutralising antibody responses against infectious SARS-CoV-2.

From What are COVID-19 neutralising antibody rapid tests and why use them?

Neutralising antibodies bind to the SARS-CoV-2 Spike protein and interfere with the virus’ ability to enter human cells. IgG antibodies are the most common antibody in blood and have the largest part to play in conferring immunity to bacteria or viruses.

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