I was recently looking at how long can Remdesivir be stored in its different forms.

I came up across several articles provided by the FDA and Gilead Sciences and others.

What caught my eye was the fact that after you reconstitute Remdesivir with sterile water you cannot store it at all! The manual and articles provided by numerous sources all say the same thing. they clearly state that you should use the reconstituted solution right away, meaning combine it with a NaCl serum. The serum then can be stored for up to 48 hours inside the fridge (no more than that).

Of course, I am not a medical professional and will not advise anyone to do anything other than what has been said inside the manual, however, I'm still curious as to how accurate this information is. specifically:

  1. Will Remdisivir reconstituted with sterile water inside its vial "Go bad" when stored in the refrigerator for a week or two?

  2. If so, how does it do so?

  3. What can you do to store reconstituted drug (e.g: Remdesivir) vials for later use? (e.g: wanting to use the drug for a longer period but at a lower daily dose)

  • Regarding question 1, I don't understand why you doubt the product literature. Do you imagine they just make this stuff up? Question 3 is off topic because it calls for advice on how to intentionally misuse a drug. Question 2 is okay but it can probably only be answered by chemists who work for the manufacturer and would be a better fit on the Chemistry exchange.
    – Carey Gregory
    May 9 '21 at 14:51
  • @CareyGregory 1. I believe that they probably have a certain standard for antivirals with a large safety margin and do not specifically test this drug per se, so their information might not be accurate. 3. Why misuse? Maybe I want to administer Remdesivir to a cat because of FIP and since the vials are for human use I cannot administer the complete vial in a single dose? and since the drug is rather expensive I cannot throw out the remaining drug. You can have a legit reason to store a reconstituted vial, from research on animals to therapeutic use for cats and dogs.
    – ATheCoder
    May 9 '21 at 15:03
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    Nobody is against sharing information. I found the reason for the storage limitation in less than a minute with a simple google search. This is why this site requires questions to demonstrate some degree of prior research. So once you know that the reason for the storage limitation is that the drug doesn't contain preservatives, which makes pathogen growth in stored solutions a risk, you could formulate a better question. What you have here is basically an XY problem.
    – Carey Gregory
    May 9 '21 at 16:29
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    Your vet is the one to ask about this since they're the one doing it and they presumably have the knowledge and experience to do it safely. You could edit this question to make it about pathogen growth in stored vials, but any form of question asking how to go about storing a vaccine contrary to manufacturer's instructions would be closed as personal medical advice.
    – Carey Gregory
    May 9 '21 at 18:00
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    Thank you, I understand now that I was in an XY Problem. However, I don't know how I should have managed to come out of it without the help of someone else. I managed to find two papers dealing with this issue.
    – ATheCoder
    May 9 '21 at 18:09

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