I know the "bupivacaine story" which [in some countries] was withdrawn from IVRA [intravenous regional anesthesia] use (aka Bier block) following some deaths, but still, for instance...
this has not prevented deaths due to its unintended intravenous administration. In the decade leading up to 2004, bupivacaine was directly responsible for the deaths of three patients in the United Kingdom as a result of accidental intravenous administration. The most recent death involved a 30-year-old parturient whose inquest was held in February 2008. [...]
In a recent survey of 135 academic anesthesiology departments by Corcoran et al., 55% vs 43% of respondents reported a preference for bupivacaine over ropivacaine for the long-acting local anesthetic of choice for peripheral nerve blockade. Factors other than safety, such as perceived quality and duration of nerve blockade, may influence choice of local anesthetic.
Topical thrombin leading to [a few] nearly fatal events (and at least one death) when being accidentally i.v. administered seems to be a similar kind of example.
Basically, a few fatal events from incorrect [i.v.] administration don't seem to be enough to completely "pull the plug" on an otherwise useful drug.
But maybe there's some such story I'm unaware of... So are there any drugs that were entirely withdrawn from market only due to adverse events following incorrect administration?