I'd like to know if impaired oxygen uptake by muscles and a return of this oxygen via the venous system has any influence on blood pH. I'm thinking about patients with for example mitochondrial myopathies.

If a person exercises, breathes heavily and oxygen uptake is limited then anaerobic metabolism would increase. This will likely lead to an increase of lactic acid, and possibly a mild acidosis. Is it possible that in such a scenario a respiratory alkalosis could also develop, similar to hyperventilating if effect of hyperventilation >> lactic acid production or could this create a mixed acid-base problem? How common is this?


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