Intravenous Immunoglobulins (IVIG) are often used to treat patients with impaired antibody production or autoimmune conditions. However, according to this paper, it can also inhibit antibody production, inhibit B-cell differentiation, inhibit the complement system, and decrease cytokine levels. Is there an increased risk of getting infections while on IVIG treatment given its immunosupressive effects?
- Jacob S, Rajabally YA. Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies. Curr Neuropharmacol. 2009;7(4):337-342. doi:10.2174/157015909790031166