Anti-VEGF(vascular endothelial growth factor)
Now my question is about pathogenesis of preeclampsia, where in due to underdeveloped placental spiral arteries, they become high resistance, low perfusion vessels.
So, by understanding of simple cardio-physiology, we can understand that if more parallel circuit of arteries was developed, it would have been lower resistance and hence better perfusion, and would not lead to Hypertension and other manifestations of preeclampsia.
Now, everywhere it is mentioned that anti-VEGF is increased in preeclampsia(as it is secreted by the placenta in response to chronic placental ischemia. Now why is placenta secreting anti-VEGF? it doesn't make any sense in decreasing the vessel growth, won't that further worsen the condition? why?
Sources that tell about the anti-VEGF in preeclampsia,
The use of anti-VEGF drugs during pregnancy is controversial because they may potentially cause systemic side effects in the mother and fetal harm, as spontaneous miscarriage and preeclampsia.
Balance of VEGF and anti angiogenic factors
(topic from my text Obstetrics by DC Dutta 8ed Pg257)
Tried searching net but didn't find any hint :(