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A patient was bitten by a tick and carried the tick on his skin for 5/6 days (which got engorged at the end). Then the tick dropped spontaneously. He has been prescribed a preventive antibiotic course of 3 weeks with doxycycline 100mg. After only 3 days he dismissed the antibiotic intake, due to strong gastric reaction.
He has been prescribed a new antibiotic course of Bactrim 80/400 mg (trimethoprim/sulfamethoxazole). Due to the different mechanism of action of doxycycline in respect to Bactrim, can the patient develop a bacterial strain resistant to doxycycline?

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