Is there a collection, meta analysis or review of significant, independent studies that prove the efficacy of vaccinations? I am in discussion with a anti-vaccinationist who claims that the efficacy has not been proven. She does not trust in studies commissioned by vaccine manufacturers because she believes that they are in a conflict of interest. I have no expertise in this field, but I would like to show her that she is wrong and that the efficacy (as well as the effectiveness) of vaccinations is sufficiently proven. Can you recommend good literature?

Thanks a lot!

  • I recommend adding ”reference-request” and 'epidemiology' tag.   There are various vaccines. Which vaccine do you want to know? Commented Aug 4, 2020 at 12:03
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    Thanks, I edited the question. The conversation with the anti-vaxxer was mainly about vaccinations for babies (diphtheria, polio, whooping cough, etc.). But since she doubts the efficacy in general, it is almost irrelevant which vaccine is discussed...
    – Brokie
    Commented Aug 4, 2020 at 14:48
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    Good luck. I have yet to encounter an anti-vaxxer whose mind can be changed with any amount of data. If they were amenable to data, they wouldn't be anti-vaxxers in the first place.
    – Carey Gregory
    Commented Aug 4, 2020 at 15:03
  • @ Carey Gregory I am not a medical expert. However, I am statistically literate. I agree that anti-vaxxers tend to cling to their self-righteous beliefs. However, I also think that regulatory science tends to be closer to pseudoscience. There is a bad culture in regulatory science, like p-value universalism. When I saw the Cochrane review of Tamiflu, I was ashamed of my blind faith in the regulatory authorities. Commented Aug 4, 2020 at 15:17

1 Answer 1


How about the Cochrane Collaboration?

For example,

I found this article further. While this article is limited to the flu vaccine for the elderly, I expect that there will be many more arguments in the future.

I think the intellectual level of the segment of the population that is emotionally averse to vaccines is low. However, I am less confident these days about whether the approved drugs really have clinical significance.

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