With potential COVID-19 vaccine trials beginning around the globe, one vaccine approach is to induce the creation of antibodies in the participants.
The first phase of the trial will check whether the vaccine candidate induces the creation of antibodies to kill the coronavirus that causes COVID-19, and whether it provokes any serious adverse side effects.
Either the potential vaccine or a placebo will be given to participants.
Two doses of COVAX-19, or a placebo, will be injected into 40 healthy people between the ages of 18 and 65
As the aim of the trial is to check for the creation of antibodies, what is the purpose of having a placebo group? Would it be a reasonable assumption to conclude that it's biologically impossible for the antibody to be created in the participant on placebo?
A standard example of the placebo effect would be in pain management - wherein participants will be given a painkiller or a sugar pill. There do exist known mechanisms for these effects, however in the case of creating an antibody - how can that be possible?