As I know, one of the way tumor may metastasis is, forced by hypoxia, creating new vessels near it, connecting them to the main circulatory system and then spread cells through the blood.
If understand that correctly, can you please answer, is there information about the “metastatic” vessels diameter distribution?
I mean, what is the diameter of the vessels that tumor creates near it? Maybe capillaries(<8um)? Can cancer cells flow in aorta, for example? Which is the average vessels diameter metastases “prefer” to spread in?