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What is the purpose of using vaccines against commonly found bacteria? Since the human immune system develops at birth and shortly thereafter (via colostrum) natural defenses against common bacteria, presumably the body already has antibodies against common bacteria. What purpose is there in "innoculating" someone against such bacteria?

For example, bacteria like pneumococcus endemically colonize everyone's lungs. In one study pneumococci were found in 80% of the healthy patients studied. Of course, that is just the bacteria that were found. Undoubtedly the other 20% of the healthy patients had various colonies of pneumococcus which simply went undiscovered. So, obviously the human body is well adapted to constantly defend against pneumococcus, yet there are varieties of pneumococcal vaccine anyway. Why would this be? To make money, or is there a proven biological action that implies a benefit? By a "biological action" I mean an explanation of the immunological mechanism by which the innoculation significantly augments pre-existing T-cell/B-cell receptors for common bacteria such as pneumococcus, and has a real benefit which is not merely reduplicative.

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    Do you consider reducing hospitalizations and deaths a "proven biological action that implies a benefit?" – Carey Gregory Apr 5 '20 at 20:05
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    The logic of your question reads to me like "we found some bacteria in a place, therefore people are immune to all bacteria and vaccines aren't needed". That is to say, it is lacking any logical construction - it looks like an antivax troll. – Bryan Krause Apr 5 '20 at 20:25
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    "You know hundreds of thousands die of pneumococcus every year, right?" - This is why a vaccine is useful. This obvious logic is lacking from your question. – Bryan Krause Apr 5 '20 at 20:32
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    There's way more than one serotype of pneumococcal bacteria... – Bryan Krause Apr 5 '20 at 20:43
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    If you're looking for a biological mechanism then you really need to edit your question and clarify because that's not at all how it reads. It reads as if you believe the presence of bacteria in a healthy person proves that person has full immunity to that bacteria. – Carey Gregory Apr 5 '20 at 20:45
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As @BryanKrause points out in a comment, there are many, many, strains of Pneumococcus, many of which do not cause disease in otherwise healthy humans. The paper you referred to looked at 500 strains of Pneumococcus: "They formed smooth colonies and were for the most part avirulent for mice." That is, most of the strains they looked were not disease causing! You may be more familiar with this phenomena with E. coli and food borne disease. All of us have guts full of E. coli which we live in a symbiotic relationship with. However, if you pick up the wrong strain from a contaminated salad bar, you can get very, very, sick.

For bacteria, the species level is a fairly gross classification, and each strain may have subtle variations in the proteins presented at the surface of the bacterium. These surface proteins can play a key role in both the virulence of the bacteria, and our immune response to it. The CDC tracks 90 strains of Pneumococcus that are responsible for most serious human disease. The current pneumococcal polysaccharide vaccine is effective against 23 of those strains.. Having been exposed to one of the non-disease causing strains does not necessarily confer immunity to a disease causing train. It depends on the details of the differences between the strains.

In addition, our immune systems tend to fail as we get older. As we age our immune systems have a lessened ability to respond to new infections, and they can even "forget" how to respond to pathogens that have already been seen. That's why the CDC recommends this vaccine for adults over the age of 65, and younger adults with compromised immune systems. It isn't generally offered to healthy young people.

  • I see, that is very interesting. Can you further explain what gets forgotten by the immune system and more specifically how the innoculation re-invirgorates the antigen templating? – Tyler Durden Apr 5 '20 at 21:58
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    Did you look at the paper I linked to on the immune systems and aging? In short, as you age, you don't generate white blood cells as quickly, and the families of white blood cells that remember a disease you had when you were 17 essentially die off of old age and accidents. Immunology is incredibly complex, and you are asking me to summarize it in 500 characters. Check out a pop book on the immune system like An Elegant Defense – Charles E. Grant Apr 5 '20 at 22:16
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    (cont) As to re-invigoration: it's not that older people are completely immune compromised, it's that their immune systems are slower and less efficient. It's always a race between the multiplication of a disease causing pathogen and our body's mounting of an immune response. Neither happens instantaneously. The vaccine gives the immune system time to ramp up it's reaction to the pathogen before it's in a race with the injuries being caused by the pathogen. – Charles E. Grant Apr 5 '20 at 22:23
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There are two immune responses to an infection, primary and secondary. Vaccination makes it possible for the body to immediately switch to a secondary response. So that's why young adults are vaccinated again meningococcal disease so that they don't die from meningitis while the body is still mounting its primary immune response.

The secondary immune responses can usually prevent disease, because the pathogen is detected, attacked and destroyed before symptoms appear. In general, adults respond more rapidly to infection than children. They are able to prevent disease or reduce the severity of the disease by mounting a rapid and strong immune response to antigens they have previously experienced. In contrast, children have not experienced as many antigens and are more likely to get sick.

Memory of the infection is reinforced and long lived antibodies remain in circulation. Some infections, such as chickenpox, induce a life-long memory of infection. Other infections, such as influenza, vary from season to season to such an extent that even an adult is unable to adapt.

https://www.immune.org.nz/immunisation/immune-system-vaccination

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