It is already known that combined oral contraceptive (COCs) pills increase the risk of serious complications such as Venous Thromboembolism. However there are other options that have relatively much lower risk compared to the others.
For instance, COCs containing Drospirenone such as the brand YAZ has been known to cause a higher 6.3x the risk of blood clotting vs. older forms such as Levornorgestrel with only 4x the risk of blood clotting.
Relative risk to non-users of common progestin components used in CoCs link here:
- Levonorgestrel boosted the risk of blood clots by nearly fourfold compared to nonusers.
Gestodene boosted risk by 5.6 times.
Drospirenone boosted risk 6.3 times.
Cyproterone boosted risk 6.8 times.
Desogestrel boosted risk 7.3 times.
However, despite the higher risks, some OB-GYNs still prefer to prescribe those with higher risk to patients. One of the reasons being that Levonorgestrel is the older generation of progestin used. As reference, my girlfriend's OB-GYN prescribed YAZ (Drospirenone) as it was a newer generation COC and I believe it would help with certain conditions such as Polycystic Ovarian Syndrome (PCOS) by improving skin acne (if present) among others. But the question is if the benefit of taking risker COCs (in term of blood clotting which can do serious damage) is worth adding the extra risk for