From reading about pharmacology through the years I synthesized from my own prior research that
What is the process of calculating if a molecule is helpful and/or harmful to an organism is this:
- A researcher gives a Dose Of Drug (DOD) to an organism with a biochemical problem; from one molecule up to some reasonable amount
- The drug might have some Minimal Effective Dose (MED) by mean of treatment; likely with biological half-life.
- The first dose that is both Treating and Harming is TaHDOD, and somewhat larger dose would be lethal.
- A ratio between MED to TaHDOD, is a Margin Of Safety (MOS).
- MOS translated into a dosage is a Therapeutic Index (TI).
- To calculate TI, two different reasonable dosages are given to one group of organisms (in different, isolated periods) with the same biochemical problem
- The dosage that helps in at least 50% of the cases and isn't significantly harmful is within MOS.
More dosage == More risk ; due to Law of Mass Action.
I am having a problem to understand what is the process of calculating if a molecule is helpful\harmful to an organism in general and how to understand how biochemists calculate ratio between MED to TaHDOD.
What is the process of calculating if a molecule is helpful and/or harmful to an organism?