The 2012 study {1} reports that:

Taken together, our findings suggest that piperine, a major component of black pepper, inhibits fat cell differentiation by down-regulating the transcriptional activity of PPARγ (and LXRα) and suppressing the expression of PPARγ (and LXRα), thus leading to its potential use in the treatment of obesity-related diseases.

Has piperine been shown to be of any use in the treatment of obesity-related diseases in humans?


  • {1} Ui-Hyun Park, Hong-Suk Jeong, Eun-Young Jo, Taesun Park, Seung Kew Yoon, Eun-Joo Kim, Ji-Cheon Jeong, Soo-Jong Um. Piperine, a Component of Black Pepper, Inhibits Adipogenesis by Antagonizing PPARγ Activity in 3T3-L1 Cells. Journal of Agricultural and Food Chemistry, 2012; 60 (15): 3853 DOI: http://dx.doi.org/10.1021/jf204514a

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