I have read about mineral inefficiencies in humans such as iron insufficiency or zinc insufficiency and recently I learned on the use of bromine containing molecules (bromides) in different medical conditions and this brought me to wonder if a mineral insufficiency of bromide also occurs in humans and if it might cause some of the symptoms treated by the following substances:
- antihistamine (brompheniramine maleate)
- anticonvulsant (sodium bromide, potassium bromide) although used primarily for dogs
- commonly used short term sleep regulators (brompheniramine Maleate, brotizolam)
- rarely used long term sleep regulators (sodium bromide, potassium bromide)
- From wikipedia: "According to one study, bromine (as bromide) is an essential cofactor in the peroxidasin catalysis of sulfilimine crosslinks in collagen IV. This post-translational modification occurs in all animals, and bromine is an essential trace element for humans."
- if bromelain enzyme contains bromide (I didn't find clear information weather yes or no) - as a possible digestive aid.
Yet, I understand that exposure to too much bromide can cause a severe poisoning named bromism.
Is there a known condition of bromide insufficiency and if so, how does it treated without causing bromism?