With the raising awareness about gender identity and specifically the recognition of non-binary identities, new challenges are faced by medicine. Specifically, there are individuals who don't feel comfortable with their own sexual characteristic but they don't desire a full transition to the opposite gender. In this case, many patients seek a low dose hormone replacement therapy(or "microdosing").
Testosterone replacement therapy is considered safe in transgender men, but there isn't any study about long term effect of a low dose on non-binary biologically female individuals(reaching serum testosterone levels above female range but not in the normal male range and without hormonal suppression of the ovary function with GnRH analogs).
I wonder if anyone has experience with this. There are many questions that arise for example: will the ovary over time diminish permanently their estrogen production? Can this low dose therapy increase the risk of osteoporosis? Can it cause metabolic complications? etc.