The 2005 randomized control trial {1} concluded that:

This randomized, controlled comparative clinical trial demonstrated that rinsing twice daily with the experimental alcohol-free 0.07% CPC rinse provides antiplaque and antigingivitis efficacy similar to that of the positive control EO rinse, a recognized antiplaque and antigingivitis mouthrinse that contains alcohol.

However, the authors have a conflict of interest since they work for Procter & Gamble, which owns Crest.

The 2018 randomized control trial {2} came to the same conclusion but also has some competing interest (authors working for Johnson & Johnson Consumer Inc).

Have independent studies confirmed that alcohol-free mouthrinses have the same efficacy in terms of antiplaque and antigingivitis effect as mouthrinses that contain alcohol?


  • 1
    Great Q. I have wondered this myself, as I've heard this from dentist colleagues but haven't seen the evidence...
    – DoctorWhom
    Jul 13 '19 at 4:16

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