DIFFERENTIAL DIAGNOSIS
Differential diagnosis in an adult man with a unilateral pain in the gluteal area lasting for over a year and not worsening, without a history of trauma, infection or inflammatory arthritis or other conditions (an incomplete list):
- Degenerative disc disease (DDD) with bulging or herniating disc(s) pressing upon the spinal nerve root(s) in the lower back (lumbosacral radiculopathy)
- Often runs in families; can be caused by acute or repetitive injury
- Pain triggers: coughing, bending and certain other moves
- Pain relievers: walking, lying down (not always)
- Other common symptoms: tingling, numbness, leg weakness
- In most cases heals/improves on its own in weeks/months
- Hip conditions with pain radiating to the gluteal area
- Piriformis syndrome
- Caused by repetitive running, climbing stairs, sitting
- Pain is typically worse during sitting ("sitting intolerance")
- Ischial bursitis
- Caused by prolonged sitting
- Pain worse during sitting
- Sacroiliac joint dysfunction (sacroiliitis)
- Pain in the hip and buttock
- Worse during prolonged standing or running
- Spinal tumor
- Pain can persist during the night
- Postherpetic neuralgia - inflammation of the nerve (neuritis) due to Herpes zoster infection
- Typically (but not always) preceded by burning rash
- Constant burning pain lasting for months/years
DIAGNOSTIC PROCESS
1) History
A doctor will likely ask detailed questions about the pain location, its triggers and relievers (coughing, sitting, walking, lying down).
2) Physical examination (examples of tests)
3) Investigations
- Blood tests to exclude inflammatory conditions (specific antibodies in ankylosing spondylitis and rheumatoid arthritis, sedimentation rate, C-reactive protein...)
- X-ray is often the first imaging investigation, which can detect broken vertebra, decreased space between vertebra (suggesting degenerative disc disease) and gross changes (spurs, deformities) due to inflammation
- CT or MRI of the lower spine or the hip is done when a problem with the discs or hip joint is suspected.
- There is no specific investigation for piriformis syndrome
NOTE: This is not a complete differential diagnosis of sciatica-like pain; it is a list of causes adjusted to the "case." The list of 18 causes linked from the question is grossly repetitive.