Commonly when we talk about Acquired metabolic diseases, we refer to endocrine diseases (like Diabetic ketoacidosis, HONK, etc), electrolyte abnormalities (hyperkalemia, hyponatremia, etc), acid-base disorders (metabolic acidosis, respiratory alkalosis, etc), hyperammonemia (causing hepatic encephalopathy), hyperuricemia, nutritional deficiencies (vit def, etc), etc.
As for inherited metabolic disease, we have Inborn Errors of Metabolism (IEM).
I understand metabolic disease is any disease in which metabolic pathways inside a cell are affected. So I have questions as to whether some diseases are metabolic diseases or not.
Does drug toxicity/overdose or even drug side effect due to action at cell surface receptor come under this category? (for instance in belladonna/atropine poisoning, the toxin/drug acts at muscarinic receptors in various organs). Logic tells that action at a cell receptor affects obviously chemical reactions inside a cell. And so drug/food poisoning are acquired metabolic diseases. But I need second opinion.
Is Toxin disease due to infection (eg: clostridium difficile infection) a metabolic disease?
Is hypoxia a metabolic disease? (as in shock)
Is malignancy/cancer a metabolic disease? (because I know a lot of intracellular metabolic pathways are activated abnormally inside a cancer cell)
While logic tells me to include these disorders under metabolic disease, we don't commonly refer to them as metabolic diseases. Why is it so?
Is it true that inflammatory disease can not cause metabolic disease but metabolic disease can cause inflammatory disease (eg: hemochromatosis causing hepatitis & steatosis)?