I heard of a case where someone suffered severe migraines after a lumbar puncture.
There are two possible explanations. Firstly, the low CSF [cerebrospinal fluid] volume depletes the cushion of fluid supporting the brain and its sensitive meningeal vascular coverings, resulting in gravitational traction on the pain‐sensitive intracranial structures causing classical headache, which worsens when the patient is upright and is relieved on lying down [Hatfalvi, B. I. (1995)]. Secondly, the decrease in CSF volume may activate adenosine receptors directly, causing cerebral vasodilatation and stretching of pain‐sensitive cerebral structures, resulting in headache after lumbar puncture [Fearon, W. (1993)].
This made me wonder if it would be plausible that spinal problems such as spinal compression could cause migraines?
Fearon, W. (1993). Post-lumbar puncture headache. P&S Medical Review, 1, 1.
Hatfalvi, B. I. (1995). Postulated mechanisms for postdural puncture headache and review of laboratory models: clinical experience. Regional Anesthesia and Pain Medicine, 20(4), 329-336. PMID: 7577782
Ahmed, S. V., Jayawarna, C., & Jude, E. (2006). Post lumbar puncture headache: diagnosis and management. Postgraduate medical journal, 82(973), 713-716. doi: 10.1136/pgmj.2006.044792 PubMed Central Free Article: PMC2660496