If I read this article correctly it indicates nicotine triggers a relaxation response in rabbits. Do we know whether a similar response is triggered in humans? Is this relaxation response the same relaxation response Lissa Rankin states explains much of the placebo effect?
Note: The YouTube video is set to start at the relevant segment and is only about 3 minutes long
My layman summation of Lissa Rankin's point: When a relaxation response is activated, mental stress in the body is reduced and chemicals like oxytocin, dopamine, and endorphins are released. Certain natural healing mechanisms flourish in this state. Placebo effects basically result from an activation of this relaxation response, but you can also do things like meditate or get a massage to tap into that relaxation response to some extent.