I've heard people say that Tylenol is safe but many of us think that its safe maybe because its easily available but, what are the risks associated with Tylenol (acetaminophen/paracetamol)?

  • 1
    Define "safe" or "bad". Does "bad" mean the risks outweigh the benefits, or does "safe" mean the opposite? There are virtually no drugs that don't have side effects and risks. The question is whether or not the benefits outweigh the risks.
    – BillDOe
    Commented Jul 15, 2018 at 20:55
  • @BillDOe A comment I made on another post prompted this question, so I've edited to try to clarify.
    – Carey Gregory
    Commented Jul 15, 2018 at 23:15
  • 1
    Thx @Carey Gregory Commented Jul 16, 2018 at 0:05

1 Answer 1


The main risk of Tylenol (aka acetaminophen/paracetamol) is liver damage, as this article from the FDA advises:

This drug is generally considered safe when used according to the directions on its labeling. But taking more than the recommended amount can cause liver damage, ranging from abnormalities in liver function blood tests, to acute liver failure, and even death.

Liver damage may take awhile to develop:

You may not notice the signs and symptoms of liver damage right away because they take time to appear. Or, you may mistake early symptoms of liver damage (for example, loss of appetite, nausea, and vomiting) for something else, like the flu. Liver damage can develop into liver failure or death over several days.

RxList recommends the maximum dosage as 3250 mg (3.250 grams) per day, which is pretty much in line with everything else I've read.

As I said in comments, nearly all drugs have some sort of side effects. That said, acetaminophen appears to be safe when taken as directed. While taking acetaminophen, you need to pay close attention to any other medications you may be taking that may include acetaminophen, such as cough and cold remedies. You also need to be careful that you're not taxing your liver with other things like alcohol.

Edit: In response to comments:
The aforementioned link to RxList also advises that up to 4 grams per day may be taken under the care of a healthcare professional, who will, presumably, monitor your hepatic function. Do not take this dose unless you are under the care of said professional! This statement in no way endorses this dosage.

  • Well rxlist says the maximum supervised dose is 4g which is what is commonly prescribed. Commented Jul 30, 2018 at 20:54
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    Yes, the keyword here being "supervised" or under the care of a healthcare professional, who, I assume, will monitor one's hepatic function.
    – BillDOe
    Commented Jul 30, 2018 at 21:04
  • The reason that the dose of 3 g a day is recommended is because people inadvertently combine different sources of paracetamol so that they exceed 4 g daily. The physiological safe dose is 4 g daily. Commented Jul 30, 2018 at 21:14
  • Yes, I pointed that out in my original answer. Also, I did not want to cite the 4-gram figure because many people would not notice the word "supervised" or "healthcare professional" and assume it's safe to take 4 grams without being under the care of said professional.
    – BillDOe
    Commented Jul 30, 2018 at 21:25

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