Can increased fibrin production from joint damage promote vascular disease such as arterial blockages, particularly where obesity or markedly increased weight causes knee, hip, ankle, and spine damage?
After realizing that fibrin can play a major role in vascular blockage construction or buildup, it also became evident that anything promoting increased fibrin production (such as your body's efforts to heal joints) may play a major role in contributing to traditional heart disease. It would also go a long way in explaining why obesity itself is so problematic in arterial blockages to the heart.
Further, it would help to explain why cholesterol, by itself, does not so completely mark heart disease. For example, I would imagine that many of us, like me, know folks that have remarkably high cholesterol levels (even very high LDL), but never actually experience heart blockages. I have realized that many of these same people with longterm dangerously high LDL levels also are not (overly) obese, and particularly important to note, did not experience serious joint troubles.
However, conversely, I've witnessed person after person who has had problems with their knees, hips, back and such who consistently require stents or even open heart surgery to resolve blockages. I've also seen folks who've had minor joint problems require only a stent or two, and then suddenly when they required hip or knee replacement their blockage situation exploded and they required multiple bypasses.
While this is all anecdotal and seemingly clear via life examples, I'd be interested to see if any research has been done in this area yet to corroborate such data as I've not found anything that directly correlates this so far.