How do humans meet the brain’s glucose demand of 420kcal (105g sugar) per day on a healthy diet? Wouldn't the protein demand in case of gluconeogenesis be tremendous?


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    @NeoGenAalem, gluconeogenesis is not only from proteins but also from lactate and fats as stated in the article you linked to: "The main precursors for gluconeogenesis are lactate and alanine from muscle, glycerol from adipose tissue, and glucogenic amino acids from the diet.
    – Jan
    Commented May 3, 2018 at 6:22

1 Answer 1


Most of your diet is carbohydrates, which are or can be directly converted into sugars, Vegetables, fruits, and grains are all primarily carbohydrates. Unless you are eating a exclusively animal based diet getting glucose for the brain is not difficult.

Contrary to what fad diets claim a healthy diet contains a lot of carbohydrates. What is unhealthy is when your diet contains only refined pure carbohydrates and not the vitamins fiber and other nutrients.

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