Clindamycinum is an antibiotic used to treat skin and vaginal infections. Can people use Clindamycinum for more than 60 days or will the bacteria become resistant to it?
Why do you disbelieve the instructions?
However, with erythromycin, clindamycin, and tetracyclines, the rate of resistance is associated with point mutations in rRNA (Ross et al., 2001). Mutations in the 23SrRNA component of an E. coli equivalent nucleotide bases give varying degrees of resistance to erythromycin and clindamycin.
So, given prolonged use Propionibacterium acnes in Acne Vulgaris will become resistant to clindamycin. There will be a selection pressure for bacteria that develop the mutation.