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What is the "AGE" in AGE-associated autoantibodies? Please describe it if you can.


It was mentioned in the book "The End of Alzheimer's: The First Programme to Prevent and Reverse the Cognitive Decline of Dementia" by Dr Dale Bredesen (link to the relevant page on google.books, screenshot below).

Here is the full sentence:

For example, instead of a twentieth-century diagnosis of subjective cognitive impairment, the twenty-first-century diagnosis may be subjective cognitive impairment of types 1.5 (70 percent) and 3 (30 percent), due to grade 3 central insulin resistance, AGE-associated autoantibodies, and innate immune system activation due to Aspergillus and HLA-DR/DQ 12-3-52B interaction, with associated gliotoxin production.

enter image description here

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    A member for over a year with admirable rep on Stack Overflow... You've already got a good answer to your question, but I wonder - what did the Google (or any other search engine) show when you tried to research this? – Lucky Feb 3 '18 at 19:35
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    Instead of an uncredited screenshot a proper reference for your source an/or readable text might also be appreciated. – LаngLаngС Feb 3 '18 at 21:10
  • See @LangLangC's comment. I think you need to cite the source of the image. – Carey Gregory Feb 4 '18 at 0:56
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Advanced Glycation End-products

These are basically proteins and lipids that are glycated in a high glucose environment, e.g. in untreated diabetic patients. Wikipedia has an article about the details.

In case you need more details than Wikipedia provides: you can find numerous peer reviewed articles via Pubmed, this one for example was suggested by user Lucky.

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    I like that the answer is concise and to the point. Perhaps, to keep in line with the site policies on references, something like this abstract can be added: ncbi.nlm.nih.gov/pubmed/12616989. It illustrates the example of diabetic patients that you gave. – Lucky Feb 3 '18 at 19:28
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    I believe we are revisiting the need for references for things which are obvious – Graham Chiu Feb 3 '18 at 21:44

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