Hi I'll try to cover most topics in the subject and link sources efficiently and straight to the points. Including detox studies.
Modern toothpaste is madness for alot of reasons and the main one is that they keep using fluoride(not even it's natural form by the way,which is calcium fluoride and you very well could do without it)
(Main sources from the points below,unless I mentioned a different source comes from this website,which is a database of more than 500 studies about fluoride various health effects(organised by different health issues). http://fluoridealert.org/issues/health/
------Check out brain effect , acute toxicity(dosage) ,etc);
EPA itself (but 2004,so it probably is reduced and some subtances banned,still looking for most recent) http://www.fluoridealert.org/wp-content/pesticides/f.source.food.inerts.htm
Vitamin D and aluminum absorption. And interraction of phosphate or phosphorique acid,iron ,zinc, and aluminium with fluoride.
- 2 All the harmfull effects far outweigth any benefits, which are
actually very small and most often not very different that from
people that don't use fluoride. Also no true meaningfull statistical correlationof cavities prevention or reduction from fluorated area compared to those that aren't. Cavities are caused by health and nutrition habits,enamel health,sugars and bacterias causing acidification and decay, poor dental hygiene substance choices, acids. If you take fluoride or not has little to no effect,except clogging the faulty area.
statistical value in whole cities or country are almost the same % .
3 Substances are absorbed through skin and sublingual, but how fluoride % or quantity I did not find enough studies yet. Still compiling studies about how much in ingested from mouth/enamel
3.1 But this study,although in my opinion not the best(since it has a few flaws in it's clarity),is still good to prove the point even more since it has enamel absorption as well as sublingual, because sublingual is alredy proven to increase absorption of many drugs/substances . I will find more,but this one is interresting because in the application theres no open enamel/cavity area. http://iopscience.iop.org/article/10.1088/1742-6596/884/1/012054/pdf
" SDF that is applied in the buccal or sublingual mucosa will be rapidly
absorbed into the reticulated vein located beneath the oral mucosa and then carried through the
internal jugular and braciocephalic veins until it flows into the systemic circulation and is excreted
through the urine "
4 Is supposed to be used topically to be "effective", but they still add it in water,weird huh(several MCG/L by the way ,sometimes even MG/L). - 4 In their own words it's supposed to be used topically to be "effective", but they still add it in water claiming it's beneficial for teeths,weird huh(several mcg or mg/l by the way). Source; http://fluoridealert.org/articles/50-reasons/ and alot more studies in there.
4.1 Even dentist agree that acids destroy enamel and causes increase risk
of cavity,yet tap water(and some toothpaste) contain alot of acidic
components, including(depending on area) alot of places in the United States and some parts in Canada; they are Fluorosilicic Acid/Hydrofluorosilicic Acid/silicofluoride/silicofluoric acid.
That seems very counter producting doesnt it and it also leaches city pipes either plastic or metal.
The other form added to both sources is Sodium Fluoride.
4.2 Then one might say it's for bone health, again benefits outweigth the
risk and there is much more healthy substances for bone
health/strength than ingesting such a strong poison(not mentioning
other heavy metals and other toxins in tap water treated by water
factories. One should never drink that, or at minimum have it
filtered with 0.0001 micron absolute reverse osmosis,ideally which
has a activated carbon filter(block) lower than 5 or 1 micron. Also plastic
water bottles leach different bisphenols and phtalates,it's best to use ceramic or glass(and keep it cold in a cooler with bigger frozen bottles).
5 It is definetely not a essential nutrient. http://fluoridealert.org/studies/essential-nutrient/
6 It's (sometime) efficacity comes from clogging enamel/cavities/or sensitive nerve,but is more absorbed in the cases of open pathway causing toxicity. Cavities are healable naturally with good health habits(avoiding eroding) and bioactive supplementation and/or foods that will repair the tooth,combined with substances that inhibit cavity causing bacterias.
6.1 And will over time cause fluorosis from teeth or bone exposure ,it's among one of the least harmfull effect.
-7 Other substances increase absorption of toxins from the skin/buccal.
"It has been reported that anionic surfactants like sodium lauryl sulfate can penetrate and interact with the skin, producing large alterations in the barrier properties. An additional mechanism for the penetration enhancement by SLS involves the hydrophobic interaction of the SLS alkyl chain with the skin structure which leaves the end sulfate group of the surfactant exposed, creating additional sites in the membrane. This results in the development of repulsive forces that separate the protein matrix, uncoil the filaments, and expose more water binding sites, hence increasing the hydration level of skin. "
7.1 From same study ; "Anionic materials tend to permeate relatively poorly through stratum corneum upon short-time exposure but permeation increases with application time. The alkyl sulfates can penetrate and destroy the integrity of the stratum corneum within hours of application. "
7.2 --- So the long term repeated exposure in that sens ,and shampoo/soaps ,are worse,but oral absorption is very effective as well.
--- Will find more studies, but it's very convincing.
8 -And there is so much more available studies to be looked at , so anyone saying fluoride should be used and telling others to take it and that theres no risk,are either very uninformed,biased and naive,to stay polite. Even if all forms of buccal absorption can(depending on fluoride content quantity) be small in one day(although small is relative to what dentist and "health agencies" call small ), on the medium,and especially on the long term it's not small at all,especially considering the acute toxicity dose of fluoride, and the fact that from skin/buccal absorption,alot of it goes straight through the blood or the brain.
9 *** Heres 2 studies about fluoride detox that show Tamarind Indicus food but mostly extract of seeds and pulp big potential for detox,including bones fluoride removal(second study).
9.1 Resumed study https://www.ncbi.nlm.nih.gov/pubmed/11840184
Full study https://www.nature.com/articles/1601287
9.2 Full study dogs and fluoride http://societyforfluorideresearch.org/wp-content/uploads/2016/07/Dog-and-fluorosis.pdf
9.3 The studies contradict themself in some nutrients absorption, but it can show fluoride interraction with those nutrients,especially magnesium. And can be due to various nutritional aspects of the test subjects, such as food and tap water anti-nutrients.
There is other substances that help in detox(more than just fluoride) but I don't have all the references, so I can't name them just yet,but they fairly easy to find.