10

Some time ago I was rejected as donor and received following rejection letter:

Just wanted to inform you that there was a positive infectious disease result for Hepatitis B. Unfortunately, we cannot take donors into the program with a positive Hepatitis B test result due to the inventory possibly being compromised.

And the following test results were attached to the rejection letter:

Hepatitis Bc IgM Ab: NON-REACTIVE (Anti-HBc IgM)

Hepatitis Bs Ag: NON-REACTIVE (HBsAg)

Hepatitis Bc Ab: REACTIVE (HBcAb)

Obviously, I don't want to be a donor, if I pose risk to someone else. So I am fine with their judgment, if it is in best interest of others.

However, now I am curious, especially after I found this CDC website and I am trying to understand under which category I fall under.

My understanding is that I fall under "Immune due to natural infection" and that it is actually impossible for me to infect others via sexual intercourse or if someone else uses my blood?

  • 1
    EXCELLENT question, and welcome! – DoctorWhom Oct 26 '17 at 3:15
  • Did you copy your results correctly? The one reactive test, HBcAb, doesn't appear in the link you provided. – Carey Gregory Oct 26 '17 at 5:11
  • @CareyGregory I just double checked everything and yes, I have copied everything correctly. Could "HBcAb" be the same thing as "anti-HBc" that does show up in the table? – user19123129129 Oct 26 '17 at 17:57
7

The Hepatitis B core antibody test is positive for IgG but negative for IgM indicating that you had the hepatitis B infection a while ago. The negative hepatitis B surface antigen test means that they are not detecting the hepatitis B in your blood when testing for the virus surface antigen. This means you've successfully cleared the infection to a very low level. You don't mention the hepatitis B surface antibody levels which are usually used to determine if you're now immune eg. after a series of hepatitis B vaccinations.

This doesn't mean you don't have the virus in your system. Immunosuppressants such as methotrexate and TNF inhibitors could still potentially reactivate the hepatitis B infection. So, you'd want to measure the HBV DNA viral load and then track that serially to see if such treatment causes a reactivation.

https://www.ncbi.nlm.nih.gov/pubmed/24805974

  • Indeed, it seems that donor clinic did not do HBsAb (Hepatitis B Surface AntiBody test). However, I just stumbled across HBsAb tests I did long time ago with my general doctor and I have had HBsAb positive there. I guess this HBsAb positive proves that I am actually naturally immune, but the donor clinic does not care about HBsAb because they just don't want to take any risk? – user19123129129 Oct 26 '17 at 18:18
  • 1
    Because it's not relevant to them. They have already established you have been infected. – Graham Chiu Oct 26 '17 at 19:50

protected by Community Apr 2 '18 at 23:15

Thank you for your interest in this question. Because it has attracted low-quality or spam answers that had to be removed, posting an answer now requires 10 reputation on this site (the association bonus does not count).

Would you like to answer one of these unanswered questions instead?

Not the answer you're looking for? Browse other questions tagged or ask your own question.